https://fphjournal.com/index.php/fphj/issue/feed 2025-03-10T08:57:34+00:00 Professor Dr. Nur Ikhwan Mohamad admin@fphjournal.com Open Journal Systems <p><strong>Fitness, Performance &amp; Health Journal (FPHJ)</strong> is a scholarly peer-reviewed academic journal publication. The journal is published online with two (2) issues per year ( June and December). Besides that, special issues of FPHJ will be published non-periodically from time to time. Fitness, Performance &amp; Health Journal is devoted to the effort of promoting evidence-based practice among practitioners within the area of physical fitness, sports performance, and public health. The journal publishes original research, systematic reviews, case studies, and short communications on current topics related to fitness, performance, and health.</p> <p>Language: English or Bahasa Melayu<br />Level of Publication: International</p> <p><strong>Authors are required to pay (MYR 250) Article Publishing Charges (APCs) as part of the publication process.</strong></p> <p>Peer Review Process<br />The submitted manuscript is first reviewed by an editor. It will be evaluated whether it is suitable with the journal focus and scope or has a major methodological flaw. These manuscripts will be sent to the reviewer anonymously (Peer Review). The reviewer's comment is then sent to the corresponding author to take the necessary actions and responses. The updated article will subsequently be examined in a meeting of the editorial board, with the final decision being forwarded to the corresponding author.</p> https://fphjournal.com/index.php/fphj/article/view/45 2025-01-11T05:15:12+00:00 Kairi Huang 20231053448@stu.ymun.edu.cn Zhou Min zmwbmin@163.com

<p>As work pressure increases, individuals are facing challenges of work-family conflict, emotional exhaustion, and reduced personal accomplishment. Objective: The present study aims to analyze the relationship between work-family conflict (WFC) and job burnout among railway employees, particularly the connection between low personal accomplishment and emotional exhaustion, and to explore the mediating roles of work interfering with family (WIF) and family interfering with work (FIW). Methods: A total of 293 employees from the Nanning Railway Bureau Group Co., Ltd. of China's Nankun Railway Line Engineering Section were surveyed using offline questionnaires. The WFC scale and the MBI-GS scale were utilized to assess work-family conflict, low personal accomplishment, and emotional exhaustion. The collected data underwent rigorous analysis using SPSS 27.0 and the Process macro program. Results: A negative correlation was identified between reduced personal accomplishment and emotional exhaustion, with the relationship between them being mediated by WIF. The mediating effect of FIW, however, was not found to be significant. Conclusions: A decline in personal accomplishment directly results in the depletion of emotional resources, with WIF partially mediating this relationship.</p>

2025-01-27T00:00:00+00:00 Copyright (c) 2025 Kairi Huang, Zhou Min https://fphjournal.com/index.php/fphj/article/view/46 2025-03-10T08:57:34+00:00 Jie Lin 3245@ymun.edu.cn Xiaomei Xie siewchoo@mahsa.edu.my Nur Fauwizah Azahar siewchoo@mahsa.edu.my Miaoge Chen siewchoo@mahsa.edu.my Siew Choo Soon siewchoo@mahsa.edu.my

<p>Pancreatic cancer (PC) is an aggressive malignancy with rapid progression and poor prognosis. The genetic heterogeneity of PC contributes to its malignancy. N6-methyladenosine (m6A) RNA modification and its regulatory factors are associated with poor prognosis and immunotherapy efficacy in PC patients. This study aimed to investigate the impact of m6A-related signature genes (m6ARS) on PC using single-cell RNA sequencing (scRNA-seq) and the Secretion Modification Region (SMR) method with multi-omics data. Methods included AddModule scoring, single-sample gene set enrichment analysis (ssGSEA), and weighted gene co-expression network analysis (WGCNA) to analyze m6ARS at the single-cell and whole transcriptome levels. The SMR method identified pathogenic genes associated with PC among m6ARS. Patients were stratified into high and low-expression groups based on m6ARS expression, revealing survival differences. Performance was evaluated using receiver operating characteristic (ROC) curves and immunohistochemistry (IHC) staining. Functional and pathway analyses, including GSEA and protein-protein interaction (PPI) networks, were conducted. The clinical value of m6ARS was explored through correlation analysis with clinical parameters, single-cell, and spatial transcriptome analyses, as well as immune microenvironment studies. Drug sensitivity analysis assessed m6ARS's potential role in chemotherapy response. Results identified a turquoise module comprising 882 m6ARS genes at both single-cell and bulk transcriptome levels. SMR analysis found 102 proteins associated with PC, with three key m6ARS genes—GCC2, UBE2D3, and TMX1—showing causal relationships with PC. TMX1 was confirmed as a prognostic marker for PC, with upregulation linked to tumor promotion and worse prognosis. Clinical and immune analyses, as well as drug sensitivity assessments, suggest TMX1's potential as a biomarker for PC prognosis and immunotherapy response. This study integrated single cell sequencing and SMR analysis to identify the shared gene TMX1, emphasizing its potential as a robust prognostic biomarker for PC and its response to immunotherapy. Therefore, targeting TMX1-mediated oxidative stress may represent a novel therapeutic strategy for PC and offer new avenues for future drug development.</p>

2025-03-26T00:00:00+00:00 Copyright (c) 2025 Lin Jie , Xiaomei Xie, Nur Fauwizah binti Azahar, Miaoge Chen, Soon Siew Choo