Clinical characteristics analysis of 1482 cases of esophageal cancer in western Guangxi, China
DOI:
https://doi.org/10.53797/fphj.v3i2.3.2024Keywords:
Esophageal cancer, Epidemiology, Clinical features, analysisAbstract
To investigate the epidemiological characteristics and trends of esophageal cancer at the Affiliated Hospital of Youjiang Medical University for Nationalities over the past 30 years, aiming to inform prevention and treatment strategies in western Guangxi. Medical records from January 1994 to December 2023 of patients diagnosed with esophageal cancer were reviewed. Patients were grouped into three 10-year intervals for comparative statistical analysis, focusing on variables such as pathological type, onset location, age, clinical stage, ethnicity, gender, treatment modality, clinical symptoms, comorbidities, and urban-rural distribution. The majority of esophageal cancer cases were males (81.24%), predominantly Han Chinese (61.07%), with the disease mostly occurring in the middle esophagus (59.99%). Squamous carcinoma was the most common pathology (90.22%), with progressive dysphagia being the prevalent symptom (78.14%). Most patients were diagnosed at advanced stages, with an increase in those receiving comprehensive treatment (47.90%).Esophageal cancer in western Guangxi shows an aging trend with higher incidence in rural areas. The predominant pathology is squamous cell carcinoma, with the middle esophagus being the common site. There is a need to enhance cancer prevention education in rural areas, tailor prevention strategies to regional clinical characteristics, and improve outcomes through routine screening and early treatment in high-risk groups.
References
Arnold, M., Ferlay, J., Van Berge Henegouwen, M. I., & Soerjomataram, I. (2020). Global burden of oesophageal and gastric cancer by histology and subsite in 2018. Gut, 69(9), 1564–1571. https://doi.org/10.1136/GUTJNL-2020-321600
Babaei, A., Shad, S., & Massey, B. T. (2020). Motility Patterns Following Esophageal Pharmacologic Provocation With Amyl Nitrite or Cholecystokinin During High-Resolution Manometry Distinguish Idiopathic vs Opioid-Induced Type 3 Achalasia. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association, 18(4), 813-821.e1. https://doi.org/10.1016/J.CGH.2019.08.014
Campbell, T. C., & Junshi, C. (1994). Diet and chronic degenerative diseases: perspectives from China. The American Journal of Clinical Nutrition, 59(5 Suppl). https://doi.org/10.1093/AJCN/59.5.1153S
Chen, Z., Lee, L., Chen, J., Collins, R., Wu, F., Guo, Y., Linksted, P., & Peto, R. (2005). Cohort profile: The Kadoorie Study of Chronic Disease in China (KSCDC). International Journal of Epidemiology, 34(6), 1243–1249. https://doi.org/10.1093/ije/dyi174
D. Max Parkin, M. F. B. J. F. P. P. (2002). Global Cancer Statistics, 2002. Global Cancer Statistics, 149(1–3), 74–108. https://doi.org/10.1016/0029-554X(78)90847-9
Huilai, L., Yanzhao, X., Zhenhua, L., Chao, H., Mingbo, W., Peng, S., Zhao, L., & Ziqiang, T. (2022). Clinicopathological characteristics and prognostic factors analysis of patients with esophageal cancer. Chinese Journal of Digestive Surgery, 21(10), 1363–1369. https://doi.org/10.3760/cma.j.cn115610-20220819-00462
Jing, S. (2012). Influential factors of esophageal cancer in residents of Hebei province: a case-control study. Chin J Public Health, 28, 454–457.
Li, J., Xu, J., Zheng, Y., Gao, Y., He, S., Li, H., Zou, K., Li, N., Tian, J., Chen, W., & He, J. (2021). Esophageal cancer: Epidemiology, risk factors and screening. Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu, 33(5), 535–547. https://doi.org/10.21147/J.ISSN.1000-9604.2021.05.01
Liu, C., & Russell, R. M. (2008). Nutrition and gastric cancer risk: an update. Nutrition Reviews, 66(5), 237–249. https://doi.org/10.1111/J.1753-4887.2008.00029.X
MacInnis, R. J., English, D. R., Hopper, J. L., & Giles, G. G. (2006). Body size and composition and the risk of gastric and oesophageal adenocarcinoma. International Journal of Cancer, 118(10), 2628–2631. https://doi.org/10.1002/IJC.21638
Mao, Y. S., Gao, S. G., Wang, Q., Shi, X. T., Li, Y., Gao, W. J., Guan, F. S., Li, X. F., Han, Y. T., Liu, Y. Y., Liu, J. F., Zhang, K., Liu, S. Y., Fu, X. N., Fang, W. T., Chen, L. Q., Wu, Q. C., Xiao, G. M., Chen, K. N., … He, J. (2020). Analysis of a registry database for esophageal cancer from high-volume centers in China. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, 33(8). https://doi.org/10.1093/DOTE/DOZ091
Pan, D., Su, M., Zhang, T., Miao, C., Fu, L., Yang, L., Song, G., Raine, P. J., Wang, S., & Sun, G. (2019). A Distinct Epidemiologic Pattern of Precancerous Lesions of Esophageal Squamous Cell Carcinoma in a High-risk Area of Huai’an, Jiangsu Province, China. Cancer Prevention Research (Philadelphia, Pa.), 12(7), 49–62. https://doi.org/10.1158/1940-6207.CAPR-18-0462
Shaoping, L. (2024). Spatial and temporal distribution characteristics research of esophageal cancer in China. Chin J Oncol, 46, 657–662. https://doi.org/10.3760/cma.j.cn112152
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/CAAC.21660
Weidong, W. (2021). Quality of life and its influencing factors in patients with esophageal cancer treated with radiotherapy in Jinzhou City. 47(1), 117–120. https://doi.org/10.12183/j.scjpm.2021.0117
Xia, D., Zhang, X. R., Ma, Y. L., Zhao, Z. J., Zhao, R., & Wang, Y. Y. (2020). Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy. Cell & Bioscience, 10(1). https://doi.org/10.1186/S13578-020-00456-6
Yamaji, T., Inoue, M., Sasazuki, S., Iwasaki, M., Kurahashi, N., Shimazu, T., & Tsugane, S. (2008). Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. International Journal of Cancer, 123(8), 1935–1940. https://doi.org/10.1002/IJC.23744
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Gao Jie, Sabah Mohammed Al-Harazi, Hong Zeng, Muhammad Za’im, Rizhu Li
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.